Mayo Clinic
GLP-1 Weight-Regain Risk Calculator
Predicting the timing of regain after stopping
Weight regain after discontinuation of semaglutide and tirzepatide: development and validation of a risk-prediction model. Romanos M et al. Journal under review, 2026  ·  ObesityWeek oral presentation, Nov 15, 2026
By using this tool, you understand that it is intended for research only and is not a substitute for clinical judgement.
Enter the details below, then press Calculate.
Medication taken
Personal characteristics at the start of treatment
BMI at start  — kg/m²
Treatment outcomes
The 3-month weight is optional; everything else is required.
Enter the patient’s details and press Calculate.
About the model, how to read the result & disclaimer →